In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Anja Fischer,
Robert Lersch,
Niklas de Andrade Krätzig,
Alexander Strong,
Mathias J Friedrich,
Julia Weber,
Thomas Engleitner,
Rupert Öllinger,
Hsi-Yu Yen,
Ursula Kohlhofer,
Irene Gonzalez-Menendez,
David Sailer,
Liz Kogan,
Mari Lahnalampi,
Saara Laukkanen,
Thorsten Kaltenbacher,
Christine Klement,
Majdaddin Rezaei,
Tim Ammon,
Juan J Montero,
Günter Schneider,
Julia Mayerle,
Mathias Heikenwälder,
Marc Schmidt-Supprian,
Leticia Quintanilla-Martinez,
Katja Steiger,
Pentao Liu,
Juan Cadiñanos,
George S Vassiliou,
Dieter Saur,
Olli Lohi,
Merja Heinäniemi,
Nathalie Conte,
Allan Bradley,
Lena Rad,
Roland Rad
Apr 17, 2023
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome in...